THQ's creative director Luis Gigliotti revealed in an interview with GameAxis that Darksiders will be a franchise and that they are anticipating a sequel.  Joystiq has stated that a Darksiders sequel was deliberate for the economic year of 2012.
An article on the Official Xbox Magazine website established that Darksiders II was expected to be released in 2012. It was publicized at E3 2011 that Darksiders II would be a launch title for the upcoming Wii U with modifications necessary to fit the controls of the Nintendo console as well as some new topographies unique to the console.
The game will take Death across multiple prisons and city hubs. City hubs feature NPCs who can give outside missions etc. One city hub will connect to a number of prisons and that one city area will feature more dungeons than the whole of the original Darksiders. Loot will also be included, dropping from meetings as rewards vacillating from 12 different armor piece categories, which can have different charms and may power up Death's Wrath Powers.
At the San Diego Comic Con, it was exposed that Michael Wincott would provide the voice of Death. On June 19, 2012, James Cosmo was announced as the voice of Maker Elder Eideard, Death's guide throughout the story.
On February 14, THQ has announced that Darksiders II would hit stores on June 26, 2012. Pre-order DLC extras for the game were also announced, for GameStop, Best Buy and Amazon. On April 18, 2012, THQ announced on their website that Darksiders II will be late until August 2012.The PC requirements were free on July 19, 2012